J Rheum Dis  
Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
Dae Jin Park, M.D.1,2, Young Bin Joo, M.D., Ph.D.1,2, So-Young Bang, M.D., Ph.D.1,2, Jiyoung Lee, M.S.2, Hye-Soon Lee, M.D., Ph.D.1,2, Sang-Cheol Bae, M.D., Ph.D., MPH1,2
1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 2Hanyang University Institute for Rheumatology, Seoul, Korea
Correspondence to: Sang-Cheol Bae, http://orcid.org/0000-0003-4658-1093
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea. E-mail: scbae@hanyang.ac.kr
Received: February 12, 2022; Revised: June 1, 2022; Accepted: June 10, 2022; Published online: July 5, 2022.
© Korean College of Rheumatology.

This is a open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: To identify the predictive factors for renal response in patients with lupus nephritis (LN).
Methods: Patients and data were extracted from a prospective systemic lupus erythematosus cohort in Korea, in which clinical data were collected at 0, 3, 6, and 12 months after induction therapy. Treatment response of LN were evaluated as a complete response (CR), partial response (PR), or non-response (NR) at 3, 6, and 12 months, respectively. Predictive factors for CR at 6 months were evaluated using multivariable Poisson regression analysis.
Results: A total of 75 patients with LN who underwent biopsy was enrolled. The mean age at diagnosis of LN was 28.9±9.7 years, and 68 (90.7%) were female. The frequencies of classes III, IV, III+V, IV+V, and V were 20.0%, 44.0%, 16.0%, 12.0%, and 8.0%, respectively. Compared to relapsed LN, new-onset LN showed a lower percentage of glomerulosclerosis (45.5% vs. 76.2%, p=0.013). The overall proportions of CR, PR, and NR at 6 and 12 months were 52.0%, 26.7%, 21.3% and 50.7%, 24.0%, 25.3%, respectively. In multivariate analysis, age at enrollment (odds ratio [OR]=1.02, p=0.022), relapsed LN (OR=0.71, p=0.037), anti-Ro antibody (OR=0.67, p=0.014), and class III LN (OR=1.48, p=0.001) were associated with CR at 6 months.
Conclusion: In our prospective cohort, class III LN was a good predictive factor for CR at 6 months in patients with LN, whereas younger age, relapsed LN, and anti-Ro antibody were poor predictive factors.
Keywords: Systemic lupus erythematosus, Lupus nephritis, Outcome assessment, Risk factor


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