Case Report

The Journal of the Korean Rheumatism Association 2010; 17(4): 422-425

Published online December 30, 2010

© Korean College of Rheumatology

류마티스관절염 환자에서 Infliximab 투여 후 발생한 수포성 유천포창 1예

박성오ㆍ이지현

메리놀병원 류마티스내과

A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis

Seong Oh Park, Ji Hyun Lee

Department of Rheumatology, Maryknoll Hospital, Busan, Korea

Correspondence to : Ji Hyun Lee

Abstract

Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximab- induced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.

Keywords Infliximab, Bullous pemphigoid, Rheumatoid arthritis

Article

Case Report

The Journal of the Korean Rheumatism Association 2010; 17(4): 422-425

Published online December 30, 2010

Copyright © Korean College of Rheumatology.

류마티스관절염 환자에서 Infliximab 투여 후 발생한 수포성 유천포창 1예

박성오ㆍ이지현

메리놀병원 류마티스내과

A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis

Seong Oh Park, Ji Hyun Lee

Department of Rheumatology, Maryknoll Hospital, Busan, Korea

Correspondence to:Ji Hyun Lee

Abstract

Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximab- induced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.

Keywords: Infliximab, Bullous pemphigoid, Rheumatoid arthritis

JRD
Jan 01, 2025 Vol.32 No.1, pp. 1~7
COVER PICTURE
Cumulative growth of rheumatology members and specialists (1980~2024). Cumulative distribution of the number of the (A) Korean College of Rheumatology members and (B) rheumatology specialists. (J Rheum Dis 2025;32:63-65)

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