Review Article
J Rheum Dis 2017; 24(1): 14-20
Published online February 28, 2017
© Korean College of Rheumatology
Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Correspondence to : Eun-Ju Chang, Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail : ejchang@amc.seoul.kr
This is a Open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
Keywords IL-32γ, Osteogenesis, Rheumatoid arthritis, Ankylosing spondylitis, Osteoporosis
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Review Article
J Rheum Dis 2017; 24(1): 14-20
Published online February 28, 2017 https://doi.org/10.4078/jrd.2017.24.1.14
Copyright © Korean College of Rheumatology.
Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Eun-Jin Lee*, Bongkun Choi*, Eui-Seung Hwang, Eun-Ju Chang
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to:Eun-Ju Chang, Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail : ejchang@amc.seoul.kr
This is a Open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
Keywords: IL-32γ, Osteogenesis, Rheumatoid arthritis, Ankylosing spondylitis, Osteoporosis
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